PBC

Podcasts

Empowering PBC Patients: APPs’ Role in Education and Support

09/18/2025

Empowering patients with Primary Biliary Cholangitis (PBC) starts with education, communication, and long-term support. In this episode, nurse practitioner Sarah Dawkins, from Duke University Medical Center, and Alison Moe, PA-C, from Atlanta Gastroenterology Associates, discuss the vital role Advanced Practice Providers (APPs) play in the longitudinal care of PBC patients. From explaining prognosis, symptoms, and treatment expectations to addressing quality-of-life challenges like fatigue, pruritus, bone density loss, and anxiety, they share practical strategies for building trust and improving patient outcomes.

You’ll hear how APPs act as the “quarterback” of care—providing education beyond the clinic visit, coordinating with multidisciplinary teams (dermatology, endocrinology, mental health, pharmacy), and connecting patients to trusted resources and support groups. Visual aids, personalized communication styles, and continuous follow-up all help patients better understand their diagnosis, medications, and long-term management.

Whether you’re a healthcare professional seeking best practices or a patient looking for clarity and support, this conversation highlights why APPs are essential in managing chronic liver disease and ensuring patients with PBC feel informed, empowered, and never alone.

Navigating Difficult Conversations: Discussing Prognosis and Lifelong Care in PBC

08/12/2025

In this engaging episode, nurse practitioners HoChong Gilles from the Central Virginia VA Healthcare System and Ann Moore from Arizona Liver Health share their expertise on navigating challenging conversations in the care of patients with Primary Biliary Cholangitis (PBC). They explore some of the most difficult topics to address—including disease chronicity, symptom management for fatigue and pruritus, and discussing prognosis—while offering practical communication strategies to build trust, encourage adherence, and provide hope. The conversation covers techniques like motivational interviewing, teach-back methods, and integrating educational resources with psychosocial support. HoChong and Ann highlight the importance of multidisciplinary collaboration, peer support networks, and advocacy groups in enhancing patient understanding and engagement. Whether managing asymptomatic patients, addressing treatment fatigue, or guiding those at risk for disease progression, this discussion delivers valuable, real-world insights for clinicians dedicated to improving quality of life and long-term outcomes in PBC care.

Collaborating Across Specialties: How APPs Can Work with Hepatologists & Other Providers in PBC Care

08/07/2025

In this engaging session from the second ADH Conference, nurse practitioner Allan Guerra and physician assistant Jhuli Patel discuss the importance of collaboration across specialties in the management of patients with Primary Biliary Cholangitis (PBC). Drawing from their respective experiences in solo and group GI practices, they highlight the critical role Advanced Practice Providers (APPs) play in identifying, diagnosing, and managing this rare liver disease. The conversation explores how effective communication with gastroenterologists, hepatologists, medical science liaisons, and multidisciplinary care teams—including social workers and office managers—can improve care coordination, medication access, and patient education. Julie and Alan also emphasize using evidence-based guidelines and leveraging EHR platforms like Athena to track labs and imaging. This session reinforces the value of teamwork and advocacy in delivering seamless, patient-centered care for individuals with PBC.

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Webcasts

Current Risk Assessment and Treatment of Patients With PBC

04/09/2026

Live from the 2026 Liver Connect Conference, Kris Kowdley, MD, Aparna Goel, MD, Pierre Gholam, MD, and Raj Vuppalanchi, MD deliver a session highlighting Current Risk Assessment and Treatment of Patients with PBC.

PBC & PSC: Advancing Diagnostics, Novel Therapeutics and Patient Centered Management Symposium

03/31/2026

Learn from Paul Kwo, MD from Stanford Medicine as he provides a presentation on Advancing Diagnostics, Novel Therapeutics, and Patient Centered Management in PBC and PSC.

Webcast: Current Risk Assessment and Treatment of Patients With PBC

03/16/2026

This webcast reviews the evolving approach to risk stratification and treatment in primary biliary cholangitis (PBC), highlighting how prognostic models, liver stiffness measurement, and biochemical response can help predict long-term outcomes. The presentation explains the role of ursodeoxycholic acid (UDCA) as first-line therapy, the importance of monitoring alkaline phosphatase and bilirubin, and how tools like the GLOBE score and FibroScan are improving personalized care for patients with PBC. It also covers newly approved second-line therapies, including elafibranor and seladelpar, with a focus on biochemical remission, itch reduction, and quality of life. This session is a practical update for clinicians managing PBC, cholestatic liver disease, fibrosis risk, and long-term treatment strategy.

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Abstract Library

Unlocking Boundless Knowledge Through Abstracts

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Masked attribution-based probing of strategies as a computational framework to align human, non-human primate, and model explanations.

07/13/2026

Muzellec Sabine (S);Alghetaa Yousif Kashef (YK);Kornblith Simon (S);Kar Kohitij (K)

[Hepatic Overlap Syndrome: Primary Sclerosing Cholangitis and Primary Biliary Cholangitis. Case Review].

06/17/2026

Aronsohn Federico (F);Poniachik Jaime (J)

Cross-Sectional Survey Protocol for Assessing Protection Intention and Self-Reported Behavior in Agricultural Heritage Tourism in Xiajin, China.

06/26/2026

Wang Chenlu (C);Bidin Sheena (S);Hafizal Mohd (M)

FAQ's

FAQ: What Are the Current Strategies for Managing Pruritus in Patients With PBC?

02/10/2026

In this educational video, Christopher Bowlus, MD, the Chief of Gastroenterology at the University of California Davis and Lena Valente Professor, provides a comprehensive overview of current pharmacologic and non-pharmacologic strategies for managing pruritus (itch) in patients with Primary Biliary Cholangitis (PBC). He explains why pruritus is one of the most common and under recognized symptoms of PBC, affecting up to 80% of patients, and highlights the importance of proactively asking patients about itch using validated tools such as the Numeric Rating Scale (NRS). The discussion explores how itch impacts quality of life, sleep, and social functioning, and reviews practical assessment strategies in clinical practice. Dr. Bowlus walks through conservative measures, historical therapies such as bile acid sequestrants and antihistamines, and their limitations, before focusing on emerging evidence-based treatments that target the underlying cholestatic mechanisms of itch. He reviews the role of PPAR agonists, including newer agents studied in phase 3 trials, as well as intestinal bile acid transport (IBAT) inhibitors that may soon expand available treatment options. The video concludes with a practical framework for individualized symptom management, emphasizing that effective control of pruritus can meaningfully improve patient outcomes and overall quality of life in PBC.

What Special Considerations Should Be Taken While Managing PBC in Pregnant Patients?

02/03/2026

In this video, Aparna Goel, MD, associate professor of medicine at Stanford University, reviews the impact of pregnancy on primary biliary cholangitis (PBC) and key considerations for managing pregnant patients with autoimmune liver disease. The discussion covers how pregnancy affects PBC laboratory markers, including the limitations of alkaline phosphatase as a biomarker, common symptom changes such as worsening pruritus, and the importance of monitoring bile acids, liver enzymes, and fat-soluble vitamins. Medication safety during pregnancy, including continued use of ursodeoxycholic acid, maternal and fetal risk assessment, monitoring for portal hypertension, and postpartum follow-up are also addressed. This practical overview highlights multidisciplinary care and real-world strategies to support safe maternal and fetal outcomes in women with PBC during pregnancy.

Diet and Lifestyle Modifications in PBC: What Can We Recommend to Our Patients?

08/26/2025

In this practical and patient-focused video, Dr. Nadege Gunn, a hepatologist based in Waco, Texas, shares essential diet and lifestyle strategies for individuals living with Primary Biliary Cholangitis (PBC). Addressing a common question—“What can I eat or do to feel better?”—Dr. Gunn highlights the benefits of a balanced, Mediterranean-style diet rich in fruits, vegetables, nuts, seeds, fish, and olive oil. She emphasizes bone health as a key concern for PBC patients, recommending adequate intake of vitamin D and calcium, resistance-based exercises, and regular weight-bearing activity. The video also stresses the importance of monitoring fat-soluble vitamin levels (A, D, E, and K), avoiding alcohol, and supplementing with a multivitamin if needed. Dr. Gunn further underscores the role of maintaining a healthy weight, staying active, avoiding smoking, and ensuring hepatitis A and B vaccinations to prevent additional liver complications. Whether you're a provider looking to guide patients or someone living with PBC seeking actionable advice, this video offers valuable lifestyle recommendations to help manage the disease and improve overall liver health.

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