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Cholestatic Pruritus Across the Age Spectrum: What Are You Missing?

When considering cholestatic pruritus across the age spectrum, a key point to remember is that while the underlying mechanism is similar, pediatric patients often present with unique challenges in diagnosis and management due to factors like limited communication abilities, potential side effects of medications, and the need for careful dosage adjustments; additionally, older adults might have co-morbidities that complicate treatment and require a more nuanced approach to managing pruritus

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Comparison of Factors Associated With 30-Day and 90-Day Readmission Among a Global Cohort of Patients Hospitalised With Cirrhosis.

09/01/2026

Idilman Ramazan (R);Haktaniyan Busra (B);Choudhury Ashok (A);Wong Florence (F);Kamath Patrick S (PS);Xie Qing (Q);Topazian Mark (M);Hayes Peter C (PC);Alvares-da-Silva Mario Reis (MR);Torre Aldo (A);George Jacob (J);Seto Wai-Kay (WK);Bush Brian (B);Silvey Scott (S);Thacker Leroy R (LR);Bajaj Jasmohan S (JS); ()

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Barriers to Hepatitis B Treatment: A Multicentre Cross-Sectional Registry and Survey Study by the Canadian Hepatitis B Network.

09/01/2026

Ko Hin Hin (HH);Vienneau Jordyn (J);Cooper Curtis L (CL);Crotty Pam (P);Congly Stephen E (SE);Brahmania Mayur (M);Ramji Alnoor (A);Kelly Erin (E);Crawley Angela M (AM);Doucette Karen (K);Meier-Stephenson Vanessa (V);Ma Mang (M);Fung Scott K (SK);Wong David K (DK);Feld Jordan (J);Faisal Nabiha (N);Kaita Kelly (K);Osiowy Carla (C);Elkhashab Magdy (M);Tam Edward (E);Wong Alexander (A);Bailey Robert (R);Wong Philip (P);Sebastiani Giada (G);Chen Tianyan (T);Conway Brian (B);Truong David (D);Tsoi Keith (K);Nudo Carmine (C);Zhu Julie (J);Poulin Sébastien (S);Shaheen Abdel-Aziz (AA);Coffin Carla S (CS)

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Characterising Hepatitis D Virus in the UK From 2011 to 2021.

09/01/2026

Simmons R (R);Ijaz S (S);Jackson R (R);Jack K (K);Mulongeni R (R);Raghu R (R);Riddell A (A);Elsharkawy A (A);Uriel A (A);Koffas A (A);Chaika A (A);Lawson A (A);Cole A (A);McEwan A (A);Brown A (A);Stone B (B);Levick C (C);Byrne D (D);Forton D (D);MacDonald D (D);Forde D (D);Nastouli E (E);Barnes E (E);Sumner E (E);Page E (E);Carey I (I);Vilar F J (FJ);Maggs J (J);Collier J (J);Shepherd J (J);Agarwal K (K);Bicknell K (K);Ala K (K);Dear K (K);Ratcliffe L (L);Bruce M (M);Zhang H (H);Rivett L (L);Maes M (M);Ankcorn M (M);Aldersley M (M);Prince M (M);Lemoine M (M);Foxton M (M);Wright M (M);Cramp M (M);Wiselka M (M);Easom N (N);Richardson P (P);Gunson R (R);Herbert R (R);Blackwell R (R);Jelley R (R);Aspinall R (R);Simpson R (R);Clewes R (R);Ahmad S (S);Mcpherson S (S);Ryder S (S);Verma S (S);Lampejo T (T);Sathyanarayana V (V);Gelson W (W);Leeman D (D);Desai M (M);Mandal S (S);Kennedy P T (PT);Irving W L (WL)

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Quantitative MRI to Assess Portal Pressure in Patients With Liver Disease: Validation at 3 T.

09/01/2026

Bradley Christopher R (CR);Scott Robert (R);Cox Eleanor F (EF);Palaniyappan Naaventhan (N);Travis Simon (S);Guha Indra Neil (IN);Aithal Guruprasad P (GP);Francis Susan T (ST)

FAQ's

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FAQ: What Are the Current Strategies for Managing Pruritus in Patients With PBC?

02/10/2026

In this educational video, Christopher Bowlus, MD, the Chief of Gastroenterology at the University of California Davis and Lena Valente Professor, provides a comprehensive overview of current pharmacologic and non-pharmacologic strategies for managing pruritus (itch) in patients with Primary Biliary Cholangitis (PBC). He explains why pruritus is one of the most common and under recognized symptoms of PBC, affecting up to 80% of patients, and highlights the importance of proactively asking patients about itch using validated tools such as the Numeric Rating Scale (NRS). The discussion explores how itch impacts quality of life, sleep, and social functioning, and reviews practical assessment strategies in clinical practice. Dr. Bowlus walks through conservative measures, historical therapies such as bile acid sequestrants and antihistamines, and their limitations, before focusing on emerging evidence-based treatments that target the underlying cholestatic mechanisms of itch. He reviews the role of PPAR agonists, including newer agents studied in phase 3 trials, as well as intestinal bile acid transport (IBAT) inhibitors that may soon expand available treatment options. The video concludes with a practical framework for individualized symptom management, emphasizing that effective control of pruritus can meaningfully improve patient outcomes and overall quality of life in PBC.

2026

Medication Review Video's