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Beyond the Mic: Exploring the Journeys of Leaders.

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Cholestatic Pruritus Across the Age Spectrum: What Are You Missing?

When considering cholestatic pruritus across the age spectrum, a key point to remember is that while the underlying mechanism is similar, pediatric patients often present with unique challenges in diagnosis and management due to factors like limited communication abilities, potential side effects of medications, and the need for careful dosage adjustments; additionally, older adults might have co-morbidities that complicate treatment and require a more nuanced approach to managing pruritus

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Interactive Expert Perspectives from CLDF on the AASLD Guidelines, HRS

The “Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases” is a comprehensive guidance on the diagnosis, evaluation, and management of the aforementioned complications of cirrhosis. It serves to replace the prior by the American Association for the Study of Liver Diseases (AASLD) guidelines on the same topics published in 2012. The Chronic Liver Disease Foundation (CLDF) is a nonprofit 501(c)(3) educational organization dedicated to raising awareness of liver disease. Members of the CLDF cirrhosis committee, actively involved in the management and treatment of patients with advanced liver disease, cirrhosis, and its complications, have provided their expert perspectives on this updated guidance. The result is this summary, which provides a streamlined version of the practical recommendations set forth in the guidance to facilitate their use in clinical practice.
Cirrhosis directly results in the development of splanchnic vasodilation, portal hypertension, and bacterial translocation. Specifically, splanchnic vasodilation leads to effective arterial underfilling associated with the activation of vasoconstrictor (e.g., renin-angiotensin) and antidiuretic (e.g., arginine vasopressin) factors. Both portal hypertension (because of increased sinusoidal) and bacterial translocation (because of gut permeability) contribute to the pathogenesis of complications associated with ascites, including hyponatremia, acute kidney injury, hepatorenal syndrome, and spontaneous bacterial infections.

Abstract Library

Unlocking Boundless Knowledge Through Abstracts

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Benign and Malignant Pediatric Liver Masses: Radiologic-Pathologic Update from the Pediatric LI-RADS Working Group.

Rees Mitchell A (MA);Acord Michael R (MR);Berklite Lara E (LE);Alazraki Adina L (AL);Chung Ellen M (EM);Khanna Geetika (G);Kolbe Amy B (AB);Morin Cara E (CE);Ro Esther (E);Schooler Gary R (GR);Syed Ali B (AB);Tang Elizabeth R (ER);Towbin Alexander J (AJ);Squires Judy H (JH)

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Association of Shoe Cushioning Perception and Comfort With Injury Risk in Leisure-Time Runners: A Secondary Analysis of a Randomised Trial.

Malisoux Laurent (L);Delattre Nicolas (N);Urhausen Axel (A);Morio Cedric (C);Theisen Daniel (D)

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Diagnosis of Hepatocellular Carcinoma Using Gadoxetic Acid-Enhanced MRI Based on LI-RADS Version 2018 and LI-RADS Modifications.

Qin Yanjin (Y);Zhang Jing (J);Xu Danyang (D);Zhou Xiaoqi (X);Ling Zhoukun (Z);Li Lujie (L);Zhao Qiaochu (Q);Dong Zhi (Z);Wang Jifei (J);Cai Hua-Song (HS);Li Hongxiang (H);Zhang Lie-Guang (LG);Feng Shi-Ting (ST)

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Therapies and Pipeline for Hepatitis B and Hepatitis D.

Lee James (J);Shah Nishali (N);Kukreja Rahul (R);Vemulapalli Bhargav (B);Rustgi Vinod (V)