Podcasts

Wilson Disease – A Condition Every Hepatologist Must Recognize

In this expert-led discussion, Dr. Carina Kugelmas, pediatric nutrition specialist at Denver Health, is joined by Dr. Michael Schilsky, Medical Director of Liver Transplantation at Yale New Haven Hospital and a leading authority on Wilson Disease. Together, they explore the complex diagnosis, presentation, and treatment of Wilson Disease—from identifying subtle neurologic and psychiatric symptoms in pediatric patients to managing acute liver failure with tailored interventions. This in-depth conversation covers diagnostic tools such as the Leipzig scoring system, 24-hour urine copper, ceruloplasmin levels, genetic testing, and emerging imaging techniques. Dr. Schilsky also breaks down current and future treatment options including chelating agents like penicillamine and trientine, zinc therapy, liver transplant criteria, and exciting innovations in gene therapy and bioavailable copper monitoring. Whether you're a pediatrician, hepatologist, or GI specialist, this session offers valuable insights into early recognition, lifelong management, and evolving therapies for Wilson Disease.