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Podcasts

Beyond the Mic: Exploring the Journeys of Leaders.

Cholestatic Pruritus Across the Age Spectrum: What Are You Missing?

When considering cholestatic pruritus across the age spectrum, a key point to remember is that while the underlying mechanism is similar, pediatric patients often present with unique challenges in diagnosis and management due to factors like limited communication abilities, potential side effects of medications, and the need for careful dosage adjustments; additionally, older adults might have co-morbidities that complicate treatment and require a more nuanced approach to managing pruritus

Webcasts

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Hepatitis B and D Infection

Joseph K. Lim, MD
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HBV/HDV Hot Topics & Virtual Roundtable

Dr. Robert Wong & Expert Panelists
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HBV, HCV, and HDV

Vinod Rustgi, MD, MBA & Nikolaos Pyrsopoulos, MD
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Publications

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Diagnosis and Management of Hepatitis Delta Virus Infection

Hepatitis D virus (HDV) depends on hepatitis B virus (HBV) to enter and exit hepatocytes and to replicate. Despite this dependency, HDV can cause severe liver disease. HDV accelerates liver fibrosis, increases the risk of hepatocellular carcinoma, and hastens hepatic decompensation compared to chronic HBV monoinfection. The Chronic Liver Disease Foundation (CLDF) formed an expert panel to publish updated guidelines on the testing, diagnosis, and management of hepatitis delta virus. The panel group performed network data review on the transmission, epidemiology, natural history, and disease sequelae of acute and chronic HDV infection. Based on current available evidence, we provide recommendations for screening, testing, diagnosis, and treatment of hepatitis D infection and review upcoming novel agents that may expand treatment options. The CLDF recommends universal HDV screening for all patients who are Hepatitis B surface antigen-positive. Initial screening should be with an assay to detect antibodies generated against HDV (anti-HDV). Patients who are positive for anti-HDV IgG antibodies should then undergo quantitative HDV RNA testing. We also provide an algorithm that describes CLDF recommendations on the screening, diagnosis, testing, and initial management of Hepatitis D infection.

Abstract Library

Unlocking Boundless Knowledge Through Abstracts

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Current evidence of bulevirtide as monotherapy compared to combination treatment with pegylated interferon for hepatitis delta.

Ruiz-Cobo Juan Carlos (JC);Palom Adriana (A);Riveiro-Barciela Mar (M);Buti María (M)

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Hepatitis D Virus Positivity among Patients from Liberia with Chronic Hepatitis B Virus Infection.

Akambase Joseph A (JA);Goble Spencer R (SR);Ali Yasmin O (YO);Ali Nahdiya M (NM);Noska Amanda J (AJ);Shaw Chelsea R (CR);Powell Jesse (J)

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NTCP ubiquitination enables HBV infection.

Appelman Monique D (MD);Nguyen Thuc-Anh (TA);Oswald Andreas (A);Lucko Aaron (A);Paulusma Coen C (CC);Protzer Ulrike (U);van de Graaf Stan F J (SFJ)