CLDF Title
Home | Contact Us | Bookmark
Centers of Educational Expertise  
Live Events Slide Library Webcasts Abstract Library LiverQ Academy Conference Highlights
Reuters Health Information: Burden of cirrhosis increasing in women

Burden of cirrhosis increasing in women

Last Updated: 2020-11-17

By Megan Brooks

NEW YORK (Reuters Health) - More women are developing cirrhosis driven largely by alcohol-related liver disease (ALD) in young women and nonalcoholic fatty liver disease (NAFLD) in older women, according to a study from Canada.

"Public-health education should be specifically directed to women regarding the risk factors for both non-alcoholic fatty liver disease and alcohol-related liver disease," Dr. Jennifer Flemming of Queen's University in Kingston, Ontario, said in a pre-recorded presentation at a press briefing November 16 at The Liver Meeting, held by the American Association for the Study of Liver Diseases (AASLD).

Using universally collected healthcare data from the province of Ontario, she and her colleagues identified more than 65,000 women diagnosed with cirrhosis from 2000 to 2017. The median age at diagnosis was 57 years. The most common causes of cirrhosis were NAFLD (63%) and ALD (16%), followed by hepatitis C (10%), autoimmune liver disease (6%), hepatitis B (5%) and "other" (1%).

Between 2000 and 2017, new cases of cirrhosis increased by 33%. The highest increases were noted in women with NAFLD-related cirrhosis who were postmenopausal. Their rate increased by almost 9% per year, Dr. Flemming told the briefing.

"An also worrisome trend" was noted in young women born after 1980 in whom ALD increased by more than 12% per year, she noted.

The researchers used the data to project new cases and causes of cirrhosis to the year 2040 in women in Ontario. "This suggested that over the next 20 years, new cases of NAFLD-related cirrhosis will increase by almost 250% in postmenopausal women, and new cases of alcohol-related cirrhosis will increase by 350% in women born after 1980," Dr. Flemming told the briefing.

The researchers also calculated rates of hepatocellular carcinoma in an exclusively female population and showed that the highest risk was in women with underlying hepatitis C and autoimmune liver disease.

"We also showed that the risk of non-malignant hepatic decompensation and death were highest in women with underlying alcohol-related liver disease and these risks were almost two fold greater than in any other etiology of cirrhosis," Dr. Flemming reported.

The findings, she concluded, suggest that "consideration for screening for NAFLD at the primary care level could be targeted to perimenopausal women during routine care to identify women most at risk for progressing to cirrhosis."

"Interventions to identify and treat young women with alcohol-use disorder and alcohol-related liver disease may have the greatest impact on the development of cirrhosis, decompensation and mortality in the future," she added.

SOURCE: American Association for the Study of Liver Diseases (AASLD) 2020 annual meeting, presented November 16, 2020.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
About CLDF
Mission Statement
Board of Trustees
Board of Advisors/Faculty
2019 GI Fellow Board of Advisors
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
CLDF Follow Us
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2021 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.