Institute for Genomic Medicine, Columbia University, New York, New York.
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina.
Gilead Sciences, Inc., Foster City, California.
Divisions of Infectious Diseases and Hepatology/Gastroenterology, Department of Medicine, Johns Hopkins University, Baltimore, Maryl.
Duke Clinical Research Institute, Durham, North Carolina.
Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.
In the ION-4 trial, hepatitis C virus relapse was rare, occurring only in African American patients, 80% receiving efavirenz for human immunodeficiency virus infection. We observed no indication that CYP2B6 polymorphisms associated with increased plasma efavirenz exposure explained the relapses.