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Abstract Details
Advancing diagnosis of current HCV infection: A key to hepatitis C elimination in the United States
J Infect Dis. 2024 Mar 11:jiae127. doi: 10.1093/infdis/jiae127. Online ahead of print.
1Division of Viral Hepatitis, Centers for Disease Control and Prevention.
Abstract
Over 2 million adults have hepatitis C virus (HCV) infection in the United States, and new infections continue to increase. Without treatment, HCV infection can lead to advanced liver disease and death. Treatment is recommended for nearly everyone with hepatitis C, resulting in a cure in >95% of people treated and raising the possibility of hepatitis C elimination. Testing is the first step to accessing life-saving treatment. CDC recommends hepatitis C screening for all adults, all pregnant persons, and anyone with risk; yet about one-third of people with hepatitis C remain unaware of their infection. Testing begins with a hepatitis C antibody test followed, when reactive, by a nucleic acid test to detect HCV RNA. This antibody-first, two-step testing strategy misses early infections and can result in incomplete diagnoses. Advancements in hepatitis C diagnostics and the U.S. regulatory landscape have created an opportunity to include viral-first testing strategies and improve hepatitis C diagnosis. This journal supplement features eight articles detailing challenges and opportunities for improving hepatitis C diagnostics in support of advancing hepatitis C elimination in the United States.