Author information

¹Department of Gastroenterology and Hepatology, Hennepin Healthcare, Minneapolis, MN, USA.

²Department of Medicine, Hennepin Healthcare, Minneapolis, MN, USA.

³Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Abstract

Introduction: Patients with chronic HCV do not respond to HBV vaccination as efficiently as the general population. We assessed if re-vaccination after HCV treatment resulted in improved response.

Methods: Previous HBV vaccine non-responders were prospectively recruited for revaccination after HCV eradication. HBsAb testing was performed one month after series completion.

Results: Follow-up HBsAb testing was performed in 31 out of 34 enrolled patients with 21 (67.7%) reactive results. There were no significant differences in HBsAb reactivity based on age, sex, race, or advanced fibrosis presence.

Conclusion: HBV vaccine non-responders should be considered for re-vaccination following HCV cure.