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Abstract Details
Hepatocellular Carcinoma in Primary Biliary Cholangitis
1Division of Hepatology, Miami VA Medical System, Department of Medicine, University of Miami Miller School of Medicine, 1201 Northwest 16th Street, Miami, FL 33125, USA; Department of Translational Medicine, Florida International University, Herbert Wertheim College of Medicine, Miami, FL, USA. Electronic address: alexander.sy3@va.gov.
2Division of Hepatology, Miami VA Medical System, Department of Medicine, University of Miami Miller School of Medicine, 1201 Northwest 16th Street, Miami, FL 33125, USA
Abstract
Hepatocellular carcinoma (HCC) is potentially fatal complication affecting patients with primary biliary cholangitis (PBC). The incidence of HCC is 13 per 1000 person-years in patients with PBC cirrhosis, but much lower at 2.7 per 1000 person-years among patients with PBC without cirrhosis. Risk factors for the development of HCC in PBC include the presence of advanced fibrosis or cirrhosis and male sex, with some studies suggesting that treatment with ursodeoxycholic acid (UDCA) and UDCA response may reduce risk.
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