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Abstract Details
Management of Chronic Hepatitis B in HIV-Coinfected Patients
1Infectious Diseases Unit, Ospedale della Murgia "F. Perinei", 70022 Altamura, Italy.
2Clinic of Infectious Diseases, Department of Clinical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
3Clinic of Infectious and Tropical Diseases, ASST Santi Paolo e Carlo, University of Milan, 20142 Milan, Italy.
Abstract
Hepatitis B virus infection occurs in approximately 7% of people living with HIV (PLWH), with substantial regional variation and higher prevalence among intravenous drug users. Early studies on the natural history of HIV/HBV coinfection demonstrated that in coinfected patients, chronic hepatitis B (CHB) has a more rapid progression than in HBV-monoinfected patients, leading to end-stage liver disease complications, including hepatocellular carcinoma. Therefore, the adequate management of CHB is considered a priority in HIV-coinfected patients. Several guidelines have highlighted this issue and have provided recommendations for preventing and treating HBV infection. This article discusses the management of liver disease in patients with HIV/HBV coinfection and summarizes the current and future therapeutic options for treating chronic hepatitis B in this setting.
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