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Abstract Details
Liver Kidney Crosstalk: Hepatorenal Syndrome
World J Hepatol. 2021 Sep 27;13(9):1058-1068. doi: 10.4254/wjh.v13.i9.1058.
1Department of Medicine, Icahn School of Medicine at Mount Sinai / NYC Health + Hospitals / Queens, New York, NY 11432, United States.
2Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, United States.
3Department of Infectious Diseases, Infectious Diseases Consultants and Academic Researchers of Egypt IDCARE, Cairo 11562, Egypt.
4Department of Medicine, Kasr Alainy Medical School, Cairo University, Cairo 11211, Egypt. ahmed.daoud84@yahoo.com.
Abstract
The dying liver causes the suffocation of the kidneys, which is a simplified way of describing the pathophysiology of hepatorenal syndrome (HRS). HRS is characterized by reversible functional renal impairment due to reduced blood supply and glomerular filtration rate, secondary to increased vasodilators. Over the years, HRS has gained much attention and focus among hepatologists and nephrologists. HRS is a diagnosis of exclusion, and in some cases, it carries a poor prognosis. Different classifications have emerged to better understand, diagnose, and promptly treat this condition. This targeted review aims to provide substantial insight into the epidemiology, pathophysiology, diagnosis, and management of HRS, shed light on the various milestones of this condition, and add to our current understanding.
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