Excessive calories from snacking increase liver fat
Excessive calories from snacking increase liver fat
By Will Boggs MD
NEW YORK (Reuters Health) - Hypercaloric diets with
increased meal frequency are associated with increases in
intrahepatic triglycerides (IHTG), researchers from The
Netherlands report.
"I hope that in the battle against obesity and in the
prevention of obesity, additional attention will be given to
eating pattern besides to caloric content and macronutrient
composition," Dr. Mireille J. Serlie from Academic Medical
Center Amsterdam told Reuters Health by email. "Also,
professionals should be aware that the metabolic handling of
nutrients might be different depending on meal timing."
High-fat diets increase IHTG in lean and obese humans, but
whether the frequency and timing of food intake influences IHTG
remains unclear.
Dr. Serlie and colleagues studied the effects of increasing
meal frequency or meal size in a six-week study of 37 lean,
Caucasian men who were randomized to one of four hypercaloric
diet groups or a control group.
The groups included: high-fat-high-sugar diet (HFHS) divided
into three meals daily (HFHS-size); HFHS divided into three
meals daily with a snack consumed 2-3 hours after each meal
(HFHS-frequency); high-sugar diet (HS) divided into three meals
daily (HS-size); and HS divided into three meals daily with a
snack consumed 2-3 hours after each meal (HS-frequency). All but
the control group received a 40% caloric surplus over the ad
libitum weight-maintaining diet.
Body mass index (BMI), IHTG, and insulin sensitivity did not
change in the control group, according to the May 6 Hepatology
online report.
Subjects in the four treatment groups gained an average of
2.5 kg during the six-week study.
IHTG increased significantly in both HFHS- and HS-frequency
groups, whereas the HFHS- and HS-size groups experienced no
change in IHTG. The IHTG increase tended to be highest in the
HS-frequency group.
Total abdominal fat increased according to the same pattern,
whereas fasting glucose and insulin sensitivity did not change
with these dietary interventions.
Plasma leptin levels increased in all four dietary
intervention groups, but glucoregulatory hormones did not
change.
When the size groups were pooled and the frequency groups
were pooled, only the frequency groups showed significantly
increased IHTG and abdominal fat.
"This suggests that when people eat more than needed and
thus increase their body weight, a snacking eating pattern
contributes independently to an unfavorable storage of fat with
possible metabolic and medical consequences in the longer term,"
Dr. Serlie said. "But we cannot draw any conclusions on the same
eating pattern in a eucaloric setting and thus stable weight
condition."
"More long-term studies are needed including females and
older subjects," Dr. Serlie said. "It would also be interesting
to study whether eating pattern has the same effect on liver and
abdominal fat in children at risk for obesity."
Dr. Claudia PMS de Oliveira from University of Sao Paulo
School of Medicine in Brazil, who has several published studies
in nonalcoholic fatty liver disease, told Reuters Health via
email, "I think that physicians should continue recommending
healthy meals and understand that there are some limitations in
this study." She specifically mentioned the small sample size
and the use of high fructose and fat in the diets.
She added, "We need randomized trials to prove this
conception, however, I believe that a low carbohydrate diet,
mainly low fructose and the use of whole-carbohydrates enriched
with high-fiber, is a better meal for reducing the induction of
carbohydrate responsive transcription factors like CHREBP or
insulin-mediated induction of SREBP1c, PPAR gamma or LXR."
SOURCE: http://bit.ly/1gIqjkv
Hepatology 2014.
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