CLDF Title
Home | Contact Us | Bookmark
MASH HCC ALCOHOL LIVER DISEASE PEDIATRIC LIVER DISEASE
Embassy of Education
Webcasts Abstract Library LiverQ Academy National Conference Regional Conferences
 
Back  
 
Reuters Health Information (2013-08-06): Scoring tool predicts outcome of liver cancer treated with arterial embolization

Clinical

Scoring tool predicts outcome of liver cancer treated with arterial embolization

Last Updated: 2013-08-06 13:49:06 -0400 (Reuters Health)

NEW YORK (Reuters Health) - A score based on four factors -- low albumin, high bilirubin and alfa-fetoprotein, and large tumor size -- is closely associated with mortality risk in patients with hepatocellular cancer (HCC) undergoing transarterial chemoembolization (TACE) or bland arterial embolization (TAE).

The scoring system "may help guide treatment selection, allow stratification in clinical trials and facilitate meaningful comparisons across reported series," according to the authors of the report in the Annals of Oncology online July 14.

As they explain, the prognosis is variable for patients with unresectable HCC for whom arterial embolization may be recommended, and a simple, reliable prognostic index would be valuable.

To develop such a scoring system, Dr. Tim Meyer at University College London and colleagues elsewhere in the UK first identified predictors of survival using data from a set of 114 patients treated with TACE/TAE. They then validated the findings in an independent dataset of 167 patients.

Cox regression analysis showed adjusted hazard ratios for mortality of 3.03 for albumin <36 g/dL; 2.21 for bilirubin >17 mcmol/L; 2.50 for alfa-fetoprotein >400 ng/mL; and 2.51 for a largest lesion >70 mm, according to the report.

The researchers assigned 1 point for each of those risk factors, and the sum of the points formed the individual prognostic score (termed the HAP score).

Median survival for a HAP score of 0, 1, 2 or >2 was 27.6, 18.5, 9.0, and 3.6 months, respectively.

The HAP score was equally predictive in the validation sample. In both cohorts, a HAP score of 2 or greater "defined poor prognosis groups which are unlikely to have benefited from TACE and might now be better served with systemic therapy or supportive care," Dr. Meyer and colleagues suggest.

Furthermore, the HAP score proved more accurate than five other scoring systems in identifying high- and low-risk groups, the team found.

Overall, they conclude, "We have defined a simple and clinically relevant prognostic index requiring the measurement of two tumour variables and two liver variables, specifically for patients undergoing TACE."

Still, they add, "It is appropriate to prospectively validate it on a larger cohort to confirm our findings."

SOURCE: http://bit.ly/16u95o8

Ann Oncol 2013.

 
 
 
 

Subscribe

Be the first to know about our latest upcoming programs and events!

CLDF

Follow us

The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2025 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.