CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2013-06-18): Maternal sulfonamides not tied to neonatal jaundice

Epidemiology

Maternal sulfonamides not tied to neonatal jaundice

Last Updated: 2013-06-18 13:20:27 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Maternal use of the short-acting sulfonamide sulfamethizole near term does not appear to increase the risk of neonatal jaundice, Danish researchers say.

While current recommendations advise against sulfamethizole in late pregnancy "due to a theoretical risk of kernicterus and jaundice in the offspring," a nationwide cohort study of nearly a million live births found no such association, lead investigator Dr. Pia Klarskov of Rigshospitalet, Copenhagen told Reuters Health by email.

"The study's conclusion is... that it is safe to use sulfamethizole in late pregnancy," Dr. Klarskov added. "Sulfamethizole is an effective and inexpensive antibiotic and, due to its now proven safety, will be a valuable contribution to treatment of bacterial infections in late pregnancy."

The agent is primarily used to treat urinary tract infections, which occur in up to 20% of pregnancies, Dr. Klarskov and colleagues noted in a paper online June 5th in Obstetrics and Gynecology. Not treating those infections can lead to higher risks for preterm delivery and other adverse outcomes.

The toxicity of sulfonamides administered to neonates is well established, but the risk of neonatal jaundice after in utero exposure to short-acting sulfonamides is not, the authors say.

When they analyzed data on 841,900 births (1995-2007), they saw jaundice within 28 days in 41,498 (4.9%) newborns.

In all, 1,823 (0.2%) of the neonates were exposed to sulfamethizole up to four weeks before birth, and 197 of these (10.8%) developed neonatal jaundice.

Before adjustment, the odds ratio was doubled in this group, but after adjustment for gestational age there was no significant association (odds ratio, 1.03) - even with exposure in the last week before birth.

The researchers suspect that in earlier reports, associations between sulfamethizole and jaundice were really due to preterm birth, which could have been a result of maternal urinary tract infection and not the antibiotic.

The new findings are also in line with an earlier Danish study involving more than 63,000 newborns.

Concerns in the literature about avoiding sulfonamides in late pregnancy are not based on studies with short-acting sulfonamides, the researchers say, adding, "The precautions regarding short-acting sulfonamides seem, therefore, to be theoretical and not scientifically or empirically based."

"It is more likely that maternal urinary tract infection may cause prematurity and thereby increased risk of neonatal jaundice," the research team concludes. "Sulfamethizole is inexpensive and effective, and it might therefore be time to disregard old hypothetical views on sulfonamides."

SOURCE: http://bit.ly/16ESJs8

Obstet Gynecol 2012.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.