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Reuters Health Information (2012-05-09): Metformin may prevent liver cancer in type 2 diabetes


Metformin may prevent liver cancer in type 2 diabetes

Last Updated: 2012-05-09 15:30:12 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Metformin appeared to lower the risk of developing liver cancer in patients with type 2 diabetes, in a meta-analysis reported online April 20th.

But the authors cautioned, in the Journal of Clinical Endocrinology and Metabolism, that more research, "including mechanistic studies, well-designed cohort studies, and possibly controlled trials, is needed."

Dr. Zhi-Jiang Zhang, with the School of Public Health at Shanghai Jiao Tong University, China, and colleagues say the risk of liver cancer is approximately doubled in patients with diabetes. Earlier studies have indicated that metformin may have a preventive effect against liver cancer as well as colorectal cancer and several other types of cancer.

To investigate further, the team searched the literature for case-control studies or cohort studies that examined the effect of metformin on hepatocellular carcinoma or primary liver cancer in patients with type 2 diabetes.

Data were abstracted from five relevant studies involving a total of 105,495 type 2 diabetics. Compared to no metformin treatment, metformin use was associated with an odds ratio of 0.38 for liver cancer (p<0.001), the authors report

"A latency time period was considered in four of the five included studies, although the possibility of reverse causation is not completely ruled out," the authors note.

They comment that metformin would be attractive for cancer chemoprevention if it is ultimately shown to reduce the risk of liver cancer, since it is well tolerated and inexpensive. "In this regard, it is instructive that the less developed countries have been disproportionately affected by liver cancer, accounting for nearly 85% of total new liver cancer cases worldwide. Thus, the affordability of metformin is important for accessibility to the general population."


J Clin Endocrino Metab 2012.

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