CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2010-12-30): Cirrhosis etiology a major factor in cancer risk


Cirrhosis etiology a major factor in cancer risk

Last Updated: 2010-12-30 18:55:16 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Patients with cirrhosis are at a significantly higher risk of cancer - not just hepatocellular carcinoma (HCC) but extrahepatic cancers (EHC) too - and a new study by U.S. researchers adds to what's already known about those risks.

One of the study's most striking findings was that cirrhosis etiology was a major factor in cancer risk.

Patients with hepatitis B or C cirrhosis (with or without alcohol use) had a five-year risk of HCC of 11.2%. Those with primary biliary cirrhosis, primary sclerosis cholangitis, alpha-one antitrypsin deficiency-related cirrhosis or alcohol-related liver disease, however, had only a 3.4% five-year probability of HCC.

In contrast, the risk of EHC was highest in patients with primary biliary cirrhosis or alcoholic cirrhosis.

For analysis of EHC risk, the researchers followed 952 patients with cirrhosis; for HCC risk, they followed 797 (after excluding patients who were positive for HCC on index CT screening or who were found to have HCC within six months of enrollment).

Overall, the cirrhotic patients had a risk of HCC that was 186 times higher than in the general population. Point estimates of HCC incidence at one, three and five years after a first negative CT scan were 1.2%, 4.4% and 7.8%, respectively, according to lead author Dr. Ken Berman of the University of Colorado School of Medicine, Denver and colleagues.

The cohort's risk of EHC was nearly double that of the general population. Point estimates of EHC incidence at one, three and five years were 2.2%, 4.5% and 6.8%, respectively. The most common EHCs were breast cancer, lung cancer and lymphoma, the research team reported online December 21st in the American Journal of Gastroenterology.

The results do not support "enhanced screening for any particular EHC in an otherwise asymptomatic patient with cirrhosis," Dr. Berman told Reuters Health by e-mail. But, he added, they do suggest a need for "heightened awareness for early warning signs of cancer in these patients."

The researchers say theirs is the first study to evaluate EHC risk in a cohort of patients with cirrhosis of all etiologies in the United States.

Both male patients and older patients were significantly more likely to be diagnosed with HCC during follow-up.


Am J Gastroenterol 2010.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
CLDF Follow Us
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2018 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.