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Reuters Health Information (2010-09-30): Statin therapy promising for nonalcoholic fatty liver disease

Clinical

Statin therapy promising for nonalcoholic fatty liver disease

Last Updated: 2010-09-30 15:24:05 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Atorvastatin with antioxidants is an effective treatment for nonalcoholic fatty liver disease (NAFLD), researchers report in the September 14th online issue of the American Journal of Gastroenterology.

They say the prevalence of NAFLD may be as high as 39%, with up to 25% of cases likely to evolve into steatohepatitis, which can ultimately lead to cirrhosis.

Noting that metabolic syndrome is present in two-thirds of obese patients with NAFLD, the research team looked at the effect of statin therapy on the condition.

"Atorvastatin is not only safe to use in patients with dyslipidemia and NAFLD but given along with vitamin E and C may also improve the presence of NAFLD," lead author Dr. Temitope Foster with the University of California, Los Angeles, told Reuters Health.

The data are from participants in the randomized St. Francis Heart Study. In that trial, 1005 men and women took either a daily combination of atorvastatin 20 mg, vitamin C 1 g, and vitamin E 1000 IU or matching placebos.

CT scans at baseline and follow-up were available for 455 patients -- 226 in the placebo group and 229 in the treatment arm. Initially there were 36 patients with NAFLD in the placebo group and 44 in the treatment arm.

At the end of a median follow-up of 3.6 years, 19 of 27 patients (70.4%) remaining in the placebo group still had NAFLD compared with 11 of 32 (34.4%) in the treatment group (odds ratio 0.29, p < 0.001), Dr. Foster and colleagues report.

"In those without NAFLD at baseline (n = 375), we found that 17.6 % of the placebo group developed NAFLD compared to 12.1 % of the treatment group," they add. The difference was not statistically significant (p=0.23).

The authors conclude that the atorvastatin/vitamin combination "lowered the risk of having moderate-to-severe hepatic steatosis by 70% in a healthy population of 80 patients with NAFLD at baseline after 4 years of therapy."

Asked if this approach should become standard for patients with NAFLD, Dr. Foster responded: "It is hard to say at this point that this should be the standard of care because while many patients with NAFLD also have dyslipidemia, not all do. We did show this treatment to be effective and safe in those with normal lipid values but these numbers were small and further studies should be conducted before making that assertion."

SOURCE: http://link.reuters.com/fat36p

Am J Gastroenterol 2010.

 
 
 
 
                 
 
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