CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2009-08-19): Pediatric HCV infection may lead to liver damage


Pediatric HCV infection may lead to liver damage

Last Updated: 2009-08-19 15:24:23 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Infection with hepatitis C virus (HCV) can cause a variety of symptoms and functional hepatic changes in children and adolescents, researchers report in the August issue of the Pediatric Infectious Disease Journal

"Our findings," lead investigator Dr. Wendy A. Henderson told Reuters Health, "indicate that pediatric patients with HCV have potentially significant symptoms and pathophysiologic liver changes related to HCV infection."

Dr. Henderson and colleagues, from the National Institutes of Health, Bethesda, Maryland, came to this conclusion after reviewing data on 62 HCV patients, 3 months to 19 years of age.

In all, 60% of these patients presented with symptoms including fatigue, joint and abdominal pain, and bruising and bleeding. In the 35 who underwent liver biopsy, 80% had evidence of inflammation. Biopsy also showed that 57% had fibrosis and 9% had steatosis. Symptoms were universally present in patients with cirrhosis or steatosis.

Overall, males were significantly more likely to be symptomatic, as were older patients. In addition, patients with a viral load below 2 million copies were five times more likely to have symptoms than those with higher values (p = 0.03). The authors suggest that this inverse association is "possibly related to the presence of comorbid conditions in 74% of the cohort."

Given these findings, Dr. Henderson concluded: "It remains to be determined if children with HCV will have amelioration or complete resolution of symptoms following treatment."

Pediatr Infect Dis J 2009;28:724-727.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.