CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2009-07-02): Hepatitis B virus mutations predict risk of hepatocellular carcinoma

Clinical

Hepatitis B virus mutations predict risk of hepatocellular carcinoma

Last Updated: 2009-07-02 16:33:49 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Specific hepatitis B virus (HBV) mutations are associated with development of hepatocellular carcinoma (HCC) and may help predict infected patients' risk for these tumors, according to a report published online July 2nd in the Journal of the National Cancer Institute.

Dr. Guangwen Cao and colleagues at Second Military Medical University in Shanghai, China conducted a meta-analysis of 43 studies involving 11,582 patients infected with HBV, including 2801 who had HCC. Using data from these papers, the researchers looked for associations between HCC and mutations in the Pre-S, enhancer II, basal core promoter, and precore regions of HBV.

The researchers report that the following were associated with an increased risk of HCC: any mutation in the HBV PreS region, C1653T (a C-to-T substitution in the enhancer II region), T1753V (a T-to-V substitution in the basal core promoter), and the double mutant A1762T/G1764A (A-to-G and G-to-A substitutions in the basal core promoter region).

The summary odds ratios of HCC associated with these polymorphisms were 3.77 for PreS mutations, 2.76 for C1653T, 2.35 for T1753V, and 3.79 for A1762T/G1764A.

These mutations "were increasingly more prevalent as chronic HBV infection progressed from the asymptomatic hepatitis B surface antigen carrier state to liver cirrhosis or HCC," comment the editors of the journal.

In the future, the authors suggest, these mutations, "alone or in combination, could be used as potential markers to identify HBV-infected patients who should receive antiviral treatment."

J Natl Cancer Inst 2009.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.