CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2009-02-04): Bevacizumab plus erlotinib promising in liver cancer

Clinical

Bevacizumab plus erlotinib promising in liver cancer

Last Updated: 2009-02-04 17:09:04 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Bevacizumab along with erlotinib shows considerable anti-tumor activity in patients who have advanced hepatocellular carcinoma (HCC), researchers report in the January 12th issue of the Journal of Clinical Oncology.

"I think the results of this trial are very encouraging," lead investigator Dr. Melanie B. Thomas told Reuters Health, "and suggest the combination is quite active in hepatocellular cancer. Most chemotherapy and biologic agents have shown none or minimal tumor responses in HCC."

Dr. Thomas of the Medical University of South Carolina, Charleston, and colleagues studied 40 patients with advanced HCC. All had received no more than one prior systemic treatment and none had disease that was amenable to surgical or regional therapy.

They were given bevacizumab 10 mg/kg every 14 days and erlotinib 150 mg per day orally, continuously over 28-day cycles.

Some 60% achieved 16-week progression-free survival. Median progression-free survival was 9.0 months and median overall survival was 15.7 months.

"Bevacizumab plus erlotinib showed a 25% response rate in this study," continued Dr. Thomas. "Overall survival is substantially longer than that published for sorafenib (10.7 months) but the only valid comparison is in a randomized trial. We are about to open a randomized phase II trial comparing bevacizumab plus erlotinib to sorafenib."

J Clin Oncol 2009;27.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.