CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2008-12-04): Good graft function seen in 5-year survivors of pediatric liver transplantation

Clinical

Good graft function seen in 5-year survivors of pediatric liver transplantation

Last Updated: 2008-12-04 8:00:35 -0400 (Reuters Health)

NEW YORK (Reuters Health) - New research indicates that most children who are 5-year survivors of liver transplantation have good graft function; however, chronic medical conditions and complications affecting extrahepatic organs are common in this patient population.

"The success of liver transplantation in children is defined by more than just excellent survival rates. Better understanding of the long-term medical considerations is of critical importance in pediatric liver transplant recipients, who by nature of their young age face a greater cumulative burden of life-long immunosuppression," Dr. Vicky Lee Ng and co-researchers emphasize in their report in the December issue of Pediatrics.

Liver transplantation has been the standard of care for life-threatening hepatic diseases for more than two decades, yet multicenter data regarding the long-term outcomes have been lacking, Dr. Ng, from the University of Toronto, and colleagues point out.

The current investigation included 461 patients who survived longer than 5 years after undergoing liver transplantation at 1 of 45 pediatric centers across North America from 1996 to 2001.

Overall, 88% of patients survived with their first graft, while 12% required one or two additional grafts.

Most patients had a functional graft at their 5-year clinic assessment, the report indicates. For immunosuppression, a calcineurin inhibitor and prednisone were used by 97% and 25% of subjects, respectively.

The risk of an episode of acute cellular rejection within 5 years was 60%. Chronic rejection was seen in 5% of patients, the authors note.

Six percent of children had posttransplant lymphoproliferative disease. Thirteen percent of subjects had a calculated glomerular filtration rate of < 90 mL/min per 1.73 m�. After adjusting for age and gender, 12% of subjects had a body mass index above the 95th percentile and 29% of patients had a height below the 10th percentile.

"This study emphasizes the need for a collaborative partnership between primary care practitioners and pediatric healthcare providers both beyond and within transplant centers to further improve outcomes for pediatric liver transplant recipients," the researchers conclude.

Pediatrics 2008;122:e1128-e1135.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.