CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2008-11-04): Extended therapy may benefit opioid-addicted youth

Clinical

Extended therapy may benefit opioid-addicted youth

Last Updated: 2008-11-04 16:00:32 -0400 (Reuters Health)

NEW YORK (Reuters Health) - New research suggests that extended treatment with buprenorphine-naloxone may be superior to short-term detox with these drugs in reducing opioid use in addicted teenagers and young adults. With either approach, however, relapse on long-term follow-up is common.

In the a study, 152 patients, 15 to 21 years of age, were randomized to receive buprenorphine-naloxone at up to 24 mg per day for 9 weeks with a taper to 12 weeks, or the drug combo at up to 14 mg per day with a taper to 14 days (detox group).

Compared with the detox group, the extended therapy group had lower rates of opioid-positive urine test results at both 4 weeks (26% vs. 61%) and 8 weeks (23% vs. 54%), lead author Dr. George E. Woody, from the University of Pennsylvania, Philadelphia, and colleagues report in the Journal of the American Medical Association for November 5.

At week 12, however, the rates in the extended therapy and detox groups were not significantly different, 43% and 51%, respectively.

Extended therapy patients were more likely to remain in treatment at week 12 than were detox patients: 70% vs. 20.5% (p < 0.001).

Participation in extended therapy was also associated with significant reductions in reported opioid use, injecting behavior, and addiction treatment outside the study (p < 0.05 for all).

Despite the gains seen, at 12-month follow-up, most patients in each group reported opioid use, the report indicates.

"The high rate of relapse seen with both medication taper protocols in the current trial ... combined with the adverse social, legal, and infectious consequences of opioid dependence -- and the risk for overdose with relapse -- makes the need for rigorous evidence in this area urgent," Dr. David A. Fiellin, from Yale University School of Medicine, New Haven, Connecticut, writes in a related editorial.

"These findings are another important reminder that there are no quick fixes for opioid dependence."

JAMA 2008;300:2003-2011,2057-2059.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.