CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2008-04-16): Hepatitis B linked to increased risk of extrahepatic bile duct cancer

Epidemiology

Hepatitis B linked to increased risk of extrahepatic bile duct cancer

Last Updated: 2008-04-16 17:16:57 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Results of a study published in the April 15th issue of the International Journal of Cancer suggest an association between hepatitis B virus (HBV) infection and an increased risk of extrahepatic bile duct cancer.

In a population-based case-control study conducted in Shanghai, China, Dr. Ann W. Hsing, of the National Cancer Institute, Bethesda, Maryland, and colleagues examined the prevalence of HBV and hepatitis C infection in 417 patients with biliary tract cancers, 517 with biliary stones, and 762 healthy controls randomly selected from the population.

Among population controls, HBsAg seroprevalence was 7.3%. Patients with extrahepatic bile duct cancer were more likely to be positive for HBsAg (14.2%). This resulted in a 2.4-fold increased risk of extrahepatic bile duct cancer.

There was no significant association between HBsAg and gallbladder cancer, ampulla of Vater cancer, gallstones, and bile duct stones.

The team observed a low prevalence of HCV infection in this population (2%), which limited the ability to detect any association with biliary disease.

"HBV induces hepatocellular carcinoma mainly by causing a chronic necroinflammatory process with regeneration of hepatocytes," Dr. Hsing's team notes. "A similar mechanism may be involved in intrahepatic and extrahepatic bile duct cancers, particularly since common progenitor stem cells differentiate into hepatocytes and cholangiocytes," they suggest.

Int J Cancer 2008;122:1849-1853.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.