CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2008-04-08): Adding radiofrequency ablation to chemoembolization ups liver cancer survival


Adding radiofrequency ablation to chemoembolization ups liver cancer survival

Last Updated: 2008-04-08 17:21:50 -0400 (Reuters Health)

NEW YORK (Reuters Health) - As a treatment for hepatocellular carcinoma larger than 3 cm, transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) leads to better survival than either modality alone, according to a report in the Journal of the American Medical Association for April 9.

This is the first randomized controlled trial to compare TACE-RFA with TACE or RFA alone in patients with larger hepatocellular carcinomas, lead author Dr. Bao-Quan Cheng, from Shandong University in Jinan, China, told Reuters Health.

The study involved 291 consecutive patients seen at a single center in China who were randomized to receive one of the three treatments. The main end point was survival.

During a median follow-up period of 28.5 months, the median survival period in the TACE-RFA group was 37 months compared with 24 and 22 months in the TACE and RFA groups, respectively. Patients treated with TACE-RFA were about 88% more likely than those treated with TACE or RFA to survive (p < 0.001 for both).

On subgroup analysis, TACE-RFA was better than RFA in improving the survival of patients with uninodular carcinoma (p = 0.001) and superior to TACE in increasing the survival of those with multinodular disease (p < 0.001).

Overall, 54% of TACE-RFA-treated patients had an objective response rate that lasted at least 6 months. By contrast, the rates in the other groups did not exceed 36%.

Dr. Cheng said that further research is needed to determine if these findings apply to patients in countries other than China. The gastroenterologist explained that in China, hepatocellular carcinoma is typically due to hepatitis B virus, whereas in Western countries, hepatitis C virus, alcohol abuse, and other diseases are the main causes.

JAMA 2008;299:1669-1677.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.