CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2008-02-01): Proteomic profiling helps identify patients with liver cancer


Proteomic profiling helps identify patients with liver cancer

Last Updated: 2008-02-01 17:07:13 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Proteomic profiling using surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) can accurately identify liver cancer, Boston-based researchers report in the January issue of Clinical Cancer Research.

"The most exciting aspect of our findings," senior investigator Dr. Nezham H. Afdhal told Reuters Health, "is that SELDI-TOF-MS was better able to detect small early hepatocellular carcinoma compared to other routine clinical blood tests, leading to a potential for improved clinical outcomes."

Dr. Afdhal of Harvard Institutes of Medicine and colleagues examined sera from 41 patients with hepatocellular carcinoma and 51 with hepatitis C cirrhosis.

The team identified an 11-peak algorithm for cancer detection. Using the established alpha-fetoprotein (AFP) biomarker cutoff, the new approach had a sensitivity of 73% and a specificity of 71%. Using the AFP-L3 cutoff, corresponding values were 63% and 94%. When the PIVKA-11 cutoff was employed, the figures were 84% and 69%.

Overall, SELDI-TOF-MS had a sensitivity of 79% and a specificity of 88% and was predictive of hepatocellular carcinoma independently of the traditional biomarkers.

Moreover, in the eight patients with tumors greater than 2 cm, SELDI-TOF-MS identified seven, whereas AFP identified only three and AFP-L3 identified only one, as did PIVKA II.

The results appear promising and are line with those of other researchers, but "these findings need to be reproduced in larger clinical cohorts and then evaluated in prospective screening trials," concluded Dr. Afdhal.

Clin Cancer Res 2008;14.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.