CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2007-11-30): Hyperglycemia tied to poor response to HCV therapy


Hyperglycemia tied to poor response to HCV therapy

Last Updated: 2007-11-30 17:49:29 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Glucose abnormalities are an independent risk factor for failure to respond to antiviral treatment in patients with chronic hepatitis C virus (HCV) infection, according to Spanish researchers.

"The relationship between hyperglycemia and the reduced treatment response in HCV-infected patients has several implications," lead investigator Dr. Albert Lecube told Reuters Health. "The first, and more obvious, is that all measures for achieving normoglycemia may help to improve treatment outcomes."

In the study, published in the October issue of the American Journal of Gastroenterology, Dr. Lecube of Hospital Vall d'Hebron, Barcelona and colleagues retrospectively compared 111 HCV patients who did not respond with 67 who had a sustained virological response (SVR) to treatment with interferon and ribavirin.

The SVR rate was 45.13% in normoglycemic patients, 28.25% in patients with impaired fasting glucose, and 15.78% in patients with type 2 diabetes.

Most (80%) of the patients had genotype 1 HCV, which was associated with failure to maintain an SVR (odds ratio, 1.55), as was the presence of glucose abnormalities (odds ratio, 2.33).

Comparison of 65 patients with glucose abnormalities and 65 controls matched for factors including age and liver fibrosis also showed a significantly lower SVR (24.6% versus 44.6%).

Measures that may improve SVR, Dr. Lecube suggested, range "from body weight loss with diet and exercise to the use of hypoglycemic agents -- oral treatment, insulin or both -- prior to and during antiviral treatment."

Am J Gastroenterol 2007;102:2189-2195.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.