CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2007-11-26): Entecavir therapy provides long-term benefit for chronic hepatitis B


Entecavir therapy provides long-term benefit for chronic hepatitis B

Last Updated: 2007-11-26 20:01:54 -0400 (Reuters Health)

NEW YORK (Reuters Health) - An extension of an earlier study shows that entecavir continues to better suppress virus compared with lamivudine after 2 years in nucleoside-naive patients with chronic e antigen-positive hepatitis B, according to a study in the November issue of Gastroenterology.

"Entecavir is now the best medication, by far, for long-term suppression of HBV infection, with a very favorable side-effect profile," lead author Dr. Robert. G. Gish of the California Pacific Medical Center, San Francisco told Reuters Health.

The double-blind, multicenter, controlled trial followed 709 patients with chronic HBV infection randomized to entecavir or lamivudine. Both groups had already received 48 weeks of either 0.5 mg of entecavir daily or 100 mg of lamivudine daily. The two groups were well matched at baseline for demographic and disease characteristics.

At the end of the first year, virologic responders were eligible to continue the blinded treatment for a total of 96 weeks.

By the end of year two, 74% patients treated with entecavir achieved HBV DNA levels below 300 copies/mL by polymerase chain reaction assay. Only 37% of those treated with lamivudine reached the same milestone.

The proportion of patients receiving entecavir who achieved normal ALT levels was 79%, compared with 68% of the lamivudine patients

None of the patients experienced virologic break-through due to entecavir resistance during the 96 weeks.

In an accompanying editorial, Dr. Emmet B. Keefe of the Stanford University School of Medicine commented that "entecavir continues to demonstrate a high genetic barrier to resistance in nucleoside-naive patients."

Gastroenterology 2007;133:1437-1444, 1718-1721.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.