CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2007-05-31): Recurrent alcohol damage unlikely post liver transplant


Recurrent alcohol damage unlikely post liver transplant

Last Updated: 2007-05-31 11:10:27 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Most patients who have undergone liver transplantation because of alcoholic cirrhosis are not likely to experience recurrent alcohol-related liver disease, French researchers report in the May issue of the American Journal of Gastroenterology.

Dr. Jerome Dumortier and colleagues at Hopital Edouard Herriot, Lyon, note that transplantation in these patients improves survival. However, some investigators have suggested that alcohol recidivism might also have a substantial clinical impact.

To investigate further, the researchers retrospectively studied data on 305 patients who had had liver transplantation at their institution because of alcoholic cirrhosis.

The global survival rate was 92.6% at 1 year and 73.4% at 10 years. This, the investigator note, is similar to the 88.8% 1-year survival and the 74.7% 10-year survival seen in patients who received transplants because of other types of cirrhosis.

Thirty-seven of the patients (12.1%) resumed alcohol consumption. At 1 year, 96.9% were alcohol free and at 10 years, 81.3% were still alcohol-free.

The researchers note that only about 3% of deaths were associated with alcoholic cirrhosis.

The investigators diagnosed de novo cases of cancer in 35 patients (11.5%). Male sex, history of smoking and de novo cancer were significantly associated with risk of increased mortality.

The researchers add that the long-term survival may be reduced in these patients because of tobacco and alcohol damage to other organs. Aero-digestive malignancies, they conclude, "are greater causes of morbidity and mortality than is recurrent alcohol liver disease."

In comments to Reuters Health, Dr. Dumortier pointed out that although benefits have been established, some questions were raised but not answered by the study. This includes what the ideal screening method is for detecting small neoplastic lesions of the aero-digestive tract post-liver transplant.

Am J Gastroenterol 2007;102:1032-1041.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.