CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-12-22): HIV infection impairs immune response to hepatitis C virus

Clinical

HIV infection impairs immune response to hepatitis C virus

Last Updated: 2006-12-22 13:40:13 -0400 (Reuters Health)

NEW YORK (Reuters Health) - HIV infection impairs the hepatitis C virus (HCV)-specific T cell response, according to a report in the December issue of PLoS Medicine.

"The loss of HCV-specific immunity that is associated with HIV may have clinical consequences, namely a susceptibility to recurrent HCV viremia with potentially high viral loads," Dr. Arthur Y. Kim from Massachusetts General Hospital, Harvard Medical School, Boston, told Reuters Health. "This helps to explain the increased rate of HCV persistence seen in HIV coinfection."

Dr. Kim and associates investigated the effects of HIV-induced T cell depletion on T cell responsiveness to both HIV-1 and HCV and examined the durability of spontaneous control of HCV in the setting of HIV-1 infection.

Spontaneous control of HCV was strongly associated with T cell proliferative responses, the authors report, but these HCV-specific responses were much less common among patients infected with both HIV and HCV.

Lower nadir CD4+ T cell counts were strongly correlated with weaker HCV-specific CD4+ lymphoproliferative responses, the results indicate, as were responses against HIV p24 antigen.

Six of 25 coinfected participants experienced recurrent HCV viremia, the researchers note, compared with none of 16 HIV-negative HCV controllers.

Moreover, the report indicates, patients with higher CD4+ T cell counts showed lower levels of HCV viremia following recurrence, and the shift from controlled to chronic HCV viremia was associated with attenuation of circulating immune responses.

"Further understanding of the immune correlates of maintaining natural HCV control and subsequent loss of control will enhance our knowledge of the quality and quantity of CF4+ and CD8+ T cell responses necessary to elicit long-lasting and cross-protective immunity," the authors conclude.

"Our further studies will address the more pressing issue of accelerated liver disease progression in HIV-positive individuals with HCV coinfection," Dr. Kim said. "We are examining whether earlier treatment of HIV-1 can affect liver disease outcomes and mortality."

PLoS Medicine 2006;12:e492.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.