CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-11-09): Mixed cryoglobulinemia may increase risk of lymphoma and mortality

Clinical

Mixed cryoglobulinemia may increase risk of lymphoma and mortality

Last Updated: 2006-11-09 18:23:22 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Mixed cryoglobulinemia that is not associated with hepatitis C virus (HCV) is associated with an increased risk of lymphoma and death, according to a report in the October 23rd issue of the Archives of Internal Medicine.

"Patients with non-HCV-related mixed cryoglobulinemia have a four-fold increased risk of developing a non-Hodgkin's lymphoma," Dr. Patrice Cacoub from Hopital La Pitie-Salpetriere, Paris, told Reuters Health. These patients should therefore undergo a yearly check-up for complications."

Dr. Cacoub and colleagues investigated the characteristics and outcomes of 133 patients with persistent mixed cryoglobulinemia without HCV.

Twenty-nine (22%) of these 133 patients had B-cell non-Hodgkin's lymphoma, the authors report. After a mean follow-up of 49.4 months, 18 had died.

Sixty-five of the patients had non-HCV-related mixed cryoglobulinemia vasculitis, the results indicate. A quarter of these patients responded completely and just over half had a partial response to corticosteroids with or without immunosuppressants.

Thirteen of the 65 patients with non-HCV-related mixed cryoglobulinemia vasculitis died, the researchers note, and all 13 had renal involvement.

"The presence of mixed cryoglobulinemia vasculitis and hypogammaglobulinemia increased the odds of developing B-cell non-Hodgkin lymphoma 4.2-fold and 6.7-fold, respectively," the investigators write.

"Patients without HCV represent approximately 10% of the population with mixed cryoglobulinemia," the authors conclude. "Patients with non-HCV-related mixed cryoglobulinemia vasculitis have a poor outcome."

Arch Intern Med 2006;166:2101-2108.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.