CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-10-16): Colchicine prevents liver cancer in patients with hepatitis virus-related cirrhosis

Clinical

Colchicine prevents liver cancer in patients with hepatitis virus-related cirrhosis

Last Updated: 2006-10-16 15:47:17 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Treatment with the anti-gout agent colchicine can help prevent hepatocellular carcinoma (HCC) in patients with hepatitis virus-related liver cirrhosis, new research suggests.

Viral hepatitis is known to increase the risk of HCC. Since cancer growth is dependent on cell proliferation, treatment with colchicine, which blocks the formation of cell microtubules needed for mitosis, could have a beneficial effect.

Although colchicine has not proven effective in slowing the progression of fibrosis in cirrhotic patients, its effects on the development of HCC have not been studied, lead author Dr. Oscar Arrieta, from the Instituto Nacional de Cancerologia in Tlalpan, Mexico, and colleagues note.

To investigate, the researchers assessed HCC occurrence in 186 patients with hepatitis virus-related liver cirrhosis who were followed for a minimum of 3 years. The subjects included 116 who received colchicine and 70 who did not.

The authors report their findings in the October 15th issue of Cancer.

Nine percent of colchicine-treated patients developed HCC compared with 29% of untreated patients, the report indicates. Colchicine therapy was also associated with a delay in the average time for HCC development: 222 months versus 150 months.

While the findings are encouraging, the researchers conclude, prospective studies "with a greater number of patients and long-term follow-up may be indicated" to confirm the current observations.

Cancer 2006.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.