CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2006-10-04): Cyclophilin inhibitor acts against hepatitis C virus

Drug & Device Development

Cyclophilin inhibitor acts against hepatitis C virus

Last Updated: 2006-10-04 16:11:29 -0400 (Reuters Health)

NEW YORK (Reuters Health) - The cyclophilin inhibitor NIM811 alone, and in combination with alpha interferon, shows strong activity against hepatitis C virus (HCV) in vitro, according to Massachusetts-based researchers.

"We are very excited about this molecule," senior investigator Dr. Kai Lin told Reuters Health. The data "clearly demonstrated NIM811 as a potent HCV inhibitor in vitro and warrant clinical investigation of the compound in hepatitis C patients, which is currently ongoing."

In the September issue of Antimicrobial Agents and Chemotherapy, Dr. Lin and colleagues at the Novartis Institutes for Biomedical Research, Cambridge note that cyclosporine binds to a family of cellular proteins, the cyclophilins, and thus inhibits HCV replication in vitro.

In a series of studies, the researchers found that N1M811 binds to cyclophilins with higher affinity than cyclosporines, and they also observe that "is devoid of the significant immunosuppressive activity associated with cyclosporine."

Moreover, use of the agent along with alpha interferon enhanced anti-HCV activity without any increase in cytotoxicity.

Thus, concluded Dr. Lin, "the compound, with a unique mechanism of action targeting host factors, provides an opportunity for combination therapy, the principle of which has also been demonstrated in our in vitro study."

Antimicrob Agents Chemother 2006;50:2976-2982.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Live CME Meetings
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2016 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.