CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-08-24): Concurrent vaccination well-tolerated and effective in infants

Public Health

Concurrent vaccination well-tolerated and effective in infants

Last Updated: 2006-08-24 12:00:57 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Administration of an established combination vaccine against diphtheria and several other major diseases together with a meningococcal C-tetanus toxoid vaccine is safe and effective in infants, according to Spanish researchers. The effects are not altered if hepatitis B vaccine is given at birth.

In the August issue of the Pediatric Infectious Disease Journal, Dr. Pilar Garcia-Corbeira of GlaxoSmithKline, Madrid, and colleagues determined if a multiple immunization approach impairs immune response. They randomized 115 healthy infants to a hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio-Haemophilus influenzae type B vaccine (Infanrix hexa, GlaxoSmithKline) administered at 2, 4 and 6 months.

The infants also received NeisVac-C (Baxter) a meningococcal C-tetanus toxoid conjugate vaccine at 2 and 4 months.

Another 115 infants were randomized to receive a hepatitis B vaccination at birth, Infanrix hexa at 2 and 6 months and a similar combination vaccine without the hepatitis B component (Infanrix-IPV Hib) at 4 months. NeisVac-C was co-administered at 2 and 4 months.

Responses of the infants in these two groups were compared with those of another 120 infants who received Infanrix hexa at 2, 4 and 6 months co-administered with a total of three doses of Meningitec (Wyeth), another meningococcal C conjugate vaccine, which employs non-toxic mutant diphtheria toxin.

All schedules were well tolerated and the team found that responses in the two NeisVac-C groups were not inferior to those in the Meningitec group. In fact, anti-prion protein antibody geometric mean concentrations were significantly higher in NeisVac-C patients.

Overall, the investigators conclude that the combination approaches along with two doses of NeisVac-C conjugate vaccine are "safe, well tolerated and immunogenic with no impairment of the response to the co-administered antigen."

Pediatr Infect Dis J 2006;25:713-720.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.