CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-06-21): Alcohol users often considered ineligible for HCV treatment

Clinical

Alcohol users often considered ineligible for HCV treatment

Last Updated: 2006-06-21 12:32:30 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Past and recent alcohol use is associated with reduced eligibility for hepatitis C virus (HCV) treatment, according to researchers. However, past and current alcohol drinkers who complete treatment have responses that are comparable to non-drinkers.

Dr. Bhupinder S. Anand, of the Michael E. DeBakey VA Medical Center, Houston, and colleagues examined the effect of alcohol use on HCV treatment outcomes. Patients were divided into the following categories: drinkers versus non-drinkers; quantity of alcohol consumed (none, less than 6 drinks/day, 6 or more drinks/day); CAGE score (less than 2 or 2 or higher); and recent alcohol use (past 12 months).

Seven hundred twenty-six subjects (18%) were treated with interferon plus ribavirin, including 142 nondrinkers and 584 drinkers. The results of the study are published in the May issue of Gastroenterology.

A total of 218 patients (30%) were HCV polymerase chain reaction negative at the end of treatment. Of these, 12% had a virologic relapse after discontinuation of therapy, resulting in an overall sustained virologic response of 18%. End-of-treatment, sustained virologic response, and treatment discontinuation rates were not affected by past alcohol use.

Forty percent of recent drinkers discontinued treatment early, compared with 26% of non-drinkers (p < 0.0002). Recent alcohol use also tended to reduce the sustained virologic response. However, when the team excluded patients who discontinued treatment, the trend in favor of non-drinkers for sustained virologic response disappeared.

"These findings were consistent among the subgroups of genotype 1 and black patients," Dr. Anand's team adds. "Our observations are clinically important because they indicate that alcohol use should not be considered an exclusion criterion when evaluating patients for anti-HCV treatment, especially in view of the fact that nearly one third of patients with HCV infection have a history of recent alcohol use."

Gastroenterology 2006;130:1607-1616.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.