CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-06-15): Obesity tied to HCV treatment failure

Clinical

Obesity tied to HCV treatment failure

Last Updated: 2006-06-15 9:55:02 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Obese patients with chronic hepatitis C virus (HCV) are more likely to have a better outcome if the underlying abnormalities caused by excessive adipose tissue are corrected, according to a review in the June issue of Hepatology.

The lead author, Dr. Michael R. Charlton of the Mayo Clinic, Rochester, Minnesota, and colleagues observe that the current understanding of obesity "is that it constitutes a metabolic condition and is not simply a function of having high body weight."

In HCV patients, they add, "obesity is associated with inflammation, insulin resistance, steatosis, progression of fibrosis, and nonresponse to treatment with interferon or peginterferon alpha and ribavirin."

Moreover, patients with both hepatitis C and obesity-related nonalcoholic fatty liver disease are at greater risk for more advanced liver disease.

Weight loss to reduce fat tissue is an important first step in improving response to treatment, say the investigators. Also important is use of drugs such as metformin and pioglitazone that improve insulin sensitivity and reduce fat accumulation in the liver. This might reverse disease progression.

Other approaches to enhance combination drug therapy may include longer duration of treatment and higher doses to counteract the decreased bioavailability. In addition, rather than basing doses on weight, use of peginterferon, for example, could be founded on a threshold body mass index.

"Treatment strategies that focus on improving underlying metabolic factors associated with poor response to combination therapy," conclude the researchers, are "more likely to overcome the low sustained viral response rates observed in obese patients infected with HCV."

Hepatology 2006;43:1177-1186.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.