CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2006-06-01): Hepatitis C worsens outcome in HIV patients


Hepatitis C worsens outcome in HIV patients

Last Updated: 2006-06-01 12:39:00 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Coinfection with hepatitis C virus (HCV) has a deleterious effect on outcome in HIV patients receiving highly active antiretroviral therapy (HAART), according to Danish researchers. Nevertheless, factors other than the infection appear to be involved.

As senior investigator Dr. Niels Obel told Reuters Health "We found that HIV patients co-infected with hepatitis C have higher mortality. However, we presume that psycho-social factors -- for example, intravenous drug abuse -- are responsible for a major part of the excess risk of death."

Dr. Obel of Odense University Hospital and colleagues conducted a prospective cohort study of all adult Danish HIV patients who began HAART over a 10-year period beginning in 1995.

Of these, 2183 (80%) were HCV-negative, 443 (16%) were HCV- positive and the remaining 108 (4%) were untested, the team reports in the May 15th issue of Clinical Infectious Diseases.

Compared to the HCV-negative group, mortality was significantly higher in the positive group (rate ratio, 2.4). This was especially true of liver disease-related mortality (rate ratio, 16.0).

Overall, say the investigators, coinfected patients "had a weaker response to HAART in terms of viral load suppression and improvement in CD4+ cell counts."

This may not simply be due to HCV, the researchers suggest. Given the apparent role of lower compliance and greater alcohol and drug abuse in HCV-HIV coinfected patients, "increased attention to these factors is required to improve the prognosis."

Clin Infect Dis 2006;42:1481-1487.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.