CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2006-03-10): Dysplastic liver nodules may be precancerous


Dysplastic liver nodules may be precancerous

Last Updated: 2006-03-10 13:42:00 -0400 (Reuters Health)

NEW YORK (Reuters Health) - In patients with chronic viral hepatitis and cirrhosis, dysplastic nodules frequently develop into hepatocellular carcinoma, Japanese researchers report.

In the February issue of Cancer, Dr. Masahiro Kobayashi of Toranomon Hospital, Tokyo and colleagues note that advances in imaging have led to detection of small nodular lesion in patients with liver disease.

To determine what factors might be associated with the development of hepatocellular carcinoma in these circumstances, the researchers observed 154 patients. None had hepatocellular carcinoma at baseline.

Over a median of 2.8 years follow-up, 29 (18.8%) of the nodules became cancerous. The rate of development was significantly higher in high-grade than low-grade dysplastic nodules.

For example, at 1 year, the development rate in high-grade nodules was 46.2% and at 5 years, 80.8%. Corresponding rates in low-grade nodules were 2.6% and 36.6%.

The annual development rate was 20% in patients with high-grade nodules and 10% in those with low-grade nodules. Cumulative rates overall, were 7.0% at 1 year, 19.9% at 3 years and 27.4% at 5 years.

Histopathologic diagnosis, a tumor diameter of more than 14 mm, age more than 60 years and having a decrease in portal blood flow in the hepatic nodule were among factors associated with cancer development.

Moreover, in conclusion, the researchers point out that on the basis of changes seen during follow-up, "enlargement of tumor diameter was the most important factor suggesting malignant transformation."

Cancer 2006;106:636-647.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.