CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2006-02-08): Lamivudine curbs hepatitis B virus reactivation in liver cancer

Clinical

Lamivudine curbs hepatitis B virus reactivation in liver cancer

Last Updated: 2006-02-08 12:48:04 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Preemptive use of lamivudine reduces overall hepatic morbidity and the severity of clinical hepatitis in patients with hepatocellular carcinoma (HCC) undergoing chemotherapy, Korean researchers report in the February issue of Hepatology.

Lead investigator Dr. Jeong Won Jang told Reuters Health that "chronic hepatitis B virus -- HBV -- carriers have a higher incidence of hepatic complications during cytotoxic therapy, most of which seem to be associated with HBV reactivation."

To evaluate the efficacy of preemptive lamivudine therapy in such circumstances, Dr. Jang and colleagues at the Catholic University of Korea, Seoul conducted a prospective, open-label study of 73 patients with HCC who were undergoing transarterial chemo-lipiodolization (TACL). Patients using epirubicin and cisplatin at monthly intervals were randomized to receive or not receive lamivudine (100 mg daily) from the start of TACL.

The researchers found that lamivudine significantly reduced overall hepatic morbidity. "In addition to the lower occurrence of viral reactivation, which was not unexpected," Dr. Jang noted, "lamivudine therapy used in this preemptive manner decreased the occurrence of overall hepatitis and the severity of any clinical hepatitis developed during chemotherapy."

The authors also observed that patients with HBV levels higher than 10,000 copies/mL were at greater risk of hepatitis due to viral reactivation.

"This population would benefit more from the preemptive therapy," Dr. Jang said, but warned that the conclusions are based upon a small number of patients. "The definitive cutoff level of viral loads that justify the preemptive use of antiviral agents," he concluded, "should be determined in future large studies."

Hepatology 2006;43:233-240.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.