CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2005-10-27): NK4 gene therapy suppresses pancreatic cancer liver metastasis in mice


NK4 gene therapy suppresses pancreatic cancer liver metastasis in mice

Last Updated: 2005-10-27 12:15:23 -0400 (Reuters Health)

NEW YORK (Reuters Health) - In mice, adenovirus-mediated NK4 gene transfer to the liver suppresses metastasis of pancreatic cancer to the liver and prolongs life, scientists from Japan report.

These findings "suggest the possibility that adenovirus-mediated (Ad-NK4) can inhibit metastatic liver tumors in postoperative pancreatic cancer patients," Dr. Mitsuhiko Murakami from Kyushu University in Fukuoka and colleagues write in the October 20th International Journal of Cancer.

In an earlier study, the researchers found that hepatocyte growth factor may be involved in the spread of postoperative pancreatic cancer and that NK4, an hepatocyte growth factor fragment, can inhibit metastatic behavior.

Dr. Murakami's group has now shown, in a mouse pancreatic cancer hepatic metastasis model, that intrasplenic injection of recombinant Ad-NK4 induces "high and relatively maintained" expression of NK4 in the liver and suppresses the number and growth of metastatic foci in the liver.

Immunohistochemical analysis of metastatic tumors showed a "remarkable decrease in microvessel density and an increase in the number of apoptotic tumor cells after treatment with Ad-NK4," they further report.

Mice treated with Ad-NK4 survived significantly longer than control mice because, according to the scientists, "tumor growth and dissemination from metastatic liver tumor were inhibited, so the onset of liver dysfunction and intraabdominal bleeding were delayed."

Dr. Murakami and colleagues think the bifunctional nature of NK4 -- as an hepatocyte growth factor antagonist and an angiogenesis inhibitor -- may lead to its development as a key drug in tumor therapy.

Int J Cancer 2005;117:160-165.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.