Reuters Health Information (2005-10-25): Hepatitis C infection associated with type 2 diabetes
Hepatitis C infection associated with type 2 diabetes
Last Updated: 2005-10-25 10:21:35 -0400 (Reuters Health)
NEW YORK (Reuters Health) - There appears to be a
connection between non-cirrhotic hepatitis C virus (HCV) infection and
type 2 diabetes, Italian researchers report in the October issue of
Dr. Alessandro Antonelli of the University of Pisa and colleagues
note that there have been some reports of an association between type 2
diabetes and HCV but at least one large study did not confirm this.
To investigate further, the researchers studied 564 patients with
non-cirrhotic HCV, 82 with non-cirrhotic hepatitis B virus (HBV)
infection and 302 matched controls.
Significantly more of the HCV patients (12.6%) had diabetes compared with the HBV patients (4.9%) and the controls (7.0%).
The data, say the researchers, suggest that HCV-related hepatitis is
associated with diabetes at a stage when liver function is largely
They also note that HCV patients with diabetes were significantly
leaner, with a body mass index of 25.7 versus 29.7 for HCV-negative
diabetics. Their LDL cholesterol concentration was also lower (3.2
versus 3.6 mmol/L).
The team calls for investigation of the underlying mechanisms and
"to test whether antiviral therapy for HCV infection may prevent the
appearance of type 2 diabetes."
Diabetes Care 2005;28:2548-2550.