CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2005-09-26): Transplant and chemoradiation combat cholangiocarcinoma

Clinical

Transplant and chemoradiation combat cholangiocarcinoma

Last Updated: 2005-09-26 16:25:28 -0400 (Reuters Health)

NEW YORK (Reuters Health) - A combination approach involving chemoradiation and liver transplantation appears effective in certain patients with hilar cholangiocarcinoma, researchers report in the September issue of Annals of Surgery.

"Combined preoperative radiotherapy and 5-FU chemosensitization with subsequent liver transplantation achieves excellent results for highly selected patients with hilar cholangiocarcinoma," investigator Dr. Charles B. Rosen told Reuters Health.

"Initial results," he added, "exceed those reported with conventional resection and compare favorably with the results of liver transplantation for other indications."

Dr. Rosen and colleagues at the Mayo Clinic, Rochester, Minnesota came to this conclusion following review of the results in patients treated over a 10-year period.

In total, 71 were considered for transplantation and 38 underwent the procedure. Operative staging was used to limit transplantation to patients with localized disease and no lymph node metastases.

Of 54 patients who were assessed for resection, 26 underwent resection. The remaining 28 had unresectable disease.

In the transplantation group, survival at 1 year was 92%, and at 2 and 5 years it was 82%. Corresponding proportions in the resection group were 82%, 48% and 21%. Moreover, the recurrence rate in the transplant patients was 13%, versus 27% in the resection group.

Thus, concluded Dr. Rosen, "hilar cholangiocarcinoma -- once a transplant contraindication -- has re-emerged as an indication for liver transplantation when combined with effective preoperative adjuvant therapy."

Ann Surg 2005;242:451-461.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.