Reuters Health Information (2005-08-05): Hepatitis A vaccine effective in children with HIV
Hepatitis A vaccine effective in children with HIV
Last Updated: 2005-08-05 14:27:19 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Vaccination against
hepatitis A using two intramuscular doses of Havrix (Glaxo SmithKline
Beecham) is immunogenic and well tolerated in children with HIV
infection, Brazilian researchers report in the August 15th issue of
Clinical Infectious Diseases.
Dr. Regina C. M. Succi and colleagues at the Federal University of
Sao Paulo note that although hepatitis A vaccination is recommended in
children living in regions with an elevated rate of the disease,
nothing is known about the response of children with vertically
acquired HIV infection.
To investigate, the researchers studied 32 children with HIV
infection, but without immunosuppression or severe symptoms, and 27
children with seroreversion. All were from Sao Paulo, a city with an
estimated hepatitis A prevalence in the general population of more than
After two doses of the vaccine, all of the children experienced
seroconversion. The injections were well tolerated. There were few
adverse advents, with an incidence similar to that seen in studies of
There were no differences in viral load variation between the
vaccinated children with HIV infection and a similar group who were not
Dr. Succi told Reuters Health that because HIV- infected children
"without severe symptoms or immune suppression can respond to hepatitis
A vaccine as well as non-HIV-infected children, we would recommend
hepatitis A vaccination of HIV- infected children who live in areas
with high and medium prevalence of hepatitis A infection."
Clin Infect Dis 2005;41:544-548.