CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2005-07-20): Ondansetron may relieve hepatitis C fatigue


Ondansetron may relieve hepatitis C fatigue

Last Updated: 2005-07-20 9:32:22 -0400 (Reuters Health)

NEW YORK (Reuters Health) - The serotonin receptor antagonist ondansetron (Zofran) reduces depression and fatigue in patients with chronic hepatitis C, French researchers report in the August 5th issue of Gut.

The fatigue associated with hepatitis C is believed to be associated with central dysfunction and altered opioid- and serotonin-mediated neuromodulation, Dr. T. Piche and colleagues observe. Because ondansetron has been shown to relieve fatigue in patients with chronic fatigue syndrome, the team theorized it would have similar clinical benefit in hepatitis C.

Dr Piche of Hopital Archet, Nice and colleagues randomly assigned 18 patients to ondansetron 4 mg twice daily for 4 weeks and 18 to placebo. Fatigue was documented via the Fatigue Impact Scale questionnaire and depression with the Beck Depression Inventory (BDI).

Ondansetron was associated with a 32.2% reduction in fatigue scores on day 15 and 37.8% on day 30. Corresponding reductions with placebo were 13.6% and 20.4%. Ondansetron continued to be associated with improvement on day 60 (31.5% reduction versus 5.8% reduction in the placebo group). Ondansetron was associated with significantly more relief of fatigue compared with placebo throughout the study period (p = 0.03).

Findings were similar for depression, with 37.3%, 35.2% and 41.9% reductions in BDI scores in the ondansetron group and 17.3%, 20.4% and 5.8% in the placebo group on days 15, 30 and 60 (p > 0.05).

Although puzzled by the prolonged effect of ondansetron beyond the treatment period, Dr. Piche and associates suggest that this effect could be related to sustained neuronal mechanisms, such as hippocampal neurogenesis.

"Considering the negative impact of fatigue on quality of life and reduced adherence to antiviral therapy in infected patients," the authors conclude, "it is crucial to further confirm these data in large multicentre trials."

In a related editorial, Dr. N. M Barnes, of the University of Birmingham comments that "Given the strong association of fatigue as a symptom of depressed patients, it would be pertinent to investigate whether the ondansetron-induced reduction in the two symptoms are interrelated."

Gut 2005;54:1169-1173.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Sponsors & Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2017 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.