Reuters Health Information (2005-04-27): Alpha1-antitrypsin deficiency tied to high mortality
Alpha1-antitrypsin deficiency tied to high mortality
Last Updated: 2005-04-27 19:30:05 -0400 (Reuters Health)
NEW YORK (Reuters Health) - People with severe
alpha1-antitrypsin deficiency are at increased risk of poor health and
death, particularly because of airflow obstruction, researchers report
in the April issue of Chest.
"The study reminds clinicians that alpha1-antitrypsin deficiency is
an important clinical problem," lead investigator Dr. James K. Stoller
told Reuters Health. "That airflow obstruction is a driver of mortality
reminds us that interventions to lessen the rate of lung function
decline are important."
Dr. Stoller of the Cleveland Clinic Foundation, Ohio, and colleagues
examined data from a national registry of patients with
Over a period of 7.2 years, a total of 204 (18.1%) of the 1129
patients died. Detailed records were available on 120 of the decedents
and death certificates were available for 56 of the remaining 84.
Emphysema was the most common underlying cause of death (72%),
followed by cirrhosis (10%). Malignancy was a cause of death in 3% and
diverticulitis was the cause in another 3%.
Analysis indicated that excess mortality was entirely ascribable to lung and liver disease.
"Clinicians must remain vigilant in monitoring both, as has also
been emphasized in the recently published American Thoracic
Society/European Respiratory Society Standards document regarding the
management of individuals with alpha1-antitrypsin deficiency," Dr.