Reuters Health Information (2005-03-07): Diabetes triples risk of liver cancer
Diabetes triples risk of liver cancer
Last Updated: 2005-03-07 19:01:27 -0400 (Reuters Health)
NEW YORK (Reuters Health) - It appears that diabetes is
an independent risk factor for hepatocellular carcinoma (HCC), raising
the risk two- to three-fold, investigators report in the April issue of
While previous studies have revealed a relationship between diabetes
and HCC (see Reuters Health reports, February 25 and September 7,
2004), results were based on referral samples and selection bias may
The current study, using data from the Surveillance, Epidemiology,
and End-Results (SEER)-Medicare database, is the first population-based
case-control study in the US that adjusted for other major risk factors
related to HCC, senior author Dr. Hashem El-Serag, at Baylor College of
Medicine in Houston, and colleagues maintain.
The study included 2161 patients aged 65 and older with diagnostic
confirmation of HCC between 1994 and 1999. The control group included
6183 randomly selected individuals.
The authors found that 43.3% of HCC patients and 19.4% of control
subjects had diabetes diagnosed during the 3 years preceding the date
of HCC diagnosis (to exclude the possibility that HCC was the cause of
After adjusting for demographic factors, the odds ratio of HCC
associated with diabetes was 3.08 (p < 0.0001). After excluding
patients with hepatitis B or C virus, alcoholic liver disease or
hemochromatosis, the odds ratio remained 2.87 to 3.11.
Hepatitis C virus alone was associated with an odds ratio of 24.42.
In the presence of diabetes, it was increased to 36.88, suggesting a
synergistic interaction between the two diseases.
"Diabetes may account for a significant proportion of patients with idiopathic HCC," Dr. El-Serag's group concludes.