CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2004-12-15): Experimental vaccine effective in animal model of amebiasis

Drug & Device Development

Experimental vaccine effective in animal model of amebiasis

Last Updated: 2004-12-15 15:58:31 -0400 (Reuters Health)

NEW YORK (Reuters Health) - An experimental vaccine protects gerbils from liver abscess caused by infection with the intestinal protozoan Entamoeba histolytica, scientists from Germany report in the December issue of the journal Infection and Immunity.

Entamoeba histolytica, the causative agent of amebiasis in humans, is endemic in large areas of the world and is thought responsible for "tens of millions of cases of dysentery and liver abscess each year," the investigators note in their report.

Despite the availability of effective therapy, illness and death associated with amebic infection have persisted, suggesting that interventions are needed to reduce or eliminate disease, Dr. Hannelore Lotter from the Bernard Nocht Institute for Tropical Medicine in Hamburg and colleagues also note.

"Since humans are the only relevant host for E. histolytica, sufficient vaccine could potentially eradicate amebiasis," they write.

To that end, Dr. Lotter's team developed an oral vaccine consisting of live attenuated Yersinia enterocolitica expressing the E. histolytica galactose-inhibitable lectin fused to the Yersinia outer protein E (YopE).

With this vaccine, "protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess," they report. "Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin," they explain.

Dr. Lotter's team speculates that the vaccine induces production of gamma interferon and tumor necrosis factor alpha via stimulated CD4 T cells, leading to activation of macrophages and finally host defense against invading E. histolytica.

Infect Immun 2004;72:7318-7321.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.