CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
Live CME Meetings Telewebs Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2004-11-11): Standard tests for hepatitis B often miss infection in dialysis patients

Epidemiology

Standard tests for hepatitis B often miss infection in dialysis patients

Last Updated: 2004-11-11 12:37:31 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Monoclonal antibody testing for hepatitis B virus (HBV) surface antigen (HbsAg) underestimates the true prevalence of the infection among patients attending hemodialysis clinics, results of a Canadian study suggest.

Dr. Gerald Y. Minuk, at the University of Manitoba in Winnipeg, and colleagues tested patients for occult HBV (serum HbsAg negative but HBV DNA positive) in the summer of 2003. The 241 patients were attending two main hemodialysis units in Winnipeg. HBV vaccination had been administered to 211, of whom 202 had completed four vaccinations.

As the authors report in the November issue of Hepatology, only two patients were positive for HbsAg. However, nine of the remaining patients were HBV DNA positive, according to screening by real-time polymerase chain reaction testing with two independent sets of primers.

Viral loads were low, the authors note, ranging from 650 to 25,000 viral copies/mL. Liver enzyme and function tests were normal. Those positive for occult HBV did not differ from their counterparts in terms of demographics, biochemistry, or results of serological testing. All but one had been vaccinated against HBV.

"Until data exist indicating whether nosocomial transmission of occult HBV can occur in susceptible dialysis patients and/or staff, screening with sensitive PCR-based assays of all dialysis patients for HBV DNA regardless of demographic, biochemical, or serological findings seems prudent," Dr. Minuk and his associates conclude.

Hepatology 2004;40:1072-1077.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Live CME Meetings
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.