Reuters Health Information (2004-07-02): Diabetes increases risk of cancer mortality
Diabetes increases risk of cancer mortality
Last Updated: 2004-07-02 11:15:10 -0400 (Reuters Health)
NEW YORK (Reuters Health) - Diabetes appears to be
independently predictive of mortality from a number of types of cancer,
according to results of a study published in the June 15th issue of the
American Journal of Epidemiology. Moreover, high body mass does not
account for these associations.
"Several studies have suggested that diabetes mellitus may alter the
risk of developing a variety of cancers, and the associations are
biologically plausible," Dr. Steven S. Coughlin, of the Centers for
Disease Control and Prevention, in Atlanta, Georgia, point out
To investigate further, the team examined the sex-specific
association between diabetes and cancer mortality in a prospective
cohort of 467,922 men and 588,321 women with no history of cancer at
baseline in 1982.
After 16 years of mortality follow-up, a significant association was
observed between diabetes and fatal colon cancer. In men the relative
risk was 1.20 and in women, it was 1.24. There also was an increased
relative risk of pancreatic cancer in men (1.48) and women (1.44).
Diabetes was significantly associated with liver cancer and bladder
cancer in men. The corresponding relative risks were 2.19 and 1.43. For
women, diabetes was significantly associated with breast cancer
(relative risk, 1.27).
The researchers note that study had a number of limitations, but
conclude that the findings "may help to clarify cancer risks for men
and women with a history of diabetes mellitus."
Am J Epidemiol 2004;159:1160-1167.