CLDF Title
Home | Contact Us | Bookmark
HBV HE HCC HCV
About CLDF Centers of Educational Expertise  
CME Dinner Meetings Webcasts Slide Library Abstract Library Conference Highlights
 
Back  
 
Reuters Health Information (2004-04-15): Active HCV infection may increase airway response to asthma treatment

Clinical

Active HCV infection may increase airway response to asthma treatment

Last Updated: 2004-04-15 12:20:24 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Active hepatitis C virus (HCV) infection may increase the bronchodilator response to inhaled oxitropium bromide in patients with asthma, Japanese researchers report. The mechanism may involve an alteration in acetylcholine-mediated airway tone.

The findings stem from a study of 52 asthma patients, including 20 with active HCV infection, 16 with inactive HCV infection, 16 without HCV infection. In all subjects, several pulmonary function tests were performed before and after oxitropium bromide administration.

Compared with other patients, those with active HCV infection showed a significantly greater increase in FEV1 with oxitropium exposure (p < 0.001), lead author Dr. Hiroshi Kanazawa and colleagues, from Osaka City University, report in the April issue of Chest. This group also experienced a significantly increase in the forced expiratory flow between 25% and 75% of FVC (p < 0.029).

Dr. Kanazawa's group hypothesizes that "CD8+ T lymphocytes activated by chronic HCV infection may induce cholinergic activation in asthma patients, at least in part through M2 [muscarinic] receptor dysfunction," the researchers state. Studies comparing "inflammatory markers and immunologic patterns between asthmatic patients with and without active HCV infection should be performed."

Chest 2004;125:1368-1371.

 
 
 
 
                 
 
HBV
Webcasts
Slide Library
Abstract Library
 
HE
CME Dinner Meeting
Webcasts
Slide Library
Abstract Library
 
HCC
Slide Library
Abstract Library
 
 
HCV
Webcasts
Slide Library
Abstract Library
 
CLDF Follow Us
   
 
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
 
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
 
Centers of
Educational Expertise
Regional Map
     
   
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2014 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.