CLDF Title
Home | Contact Us | Bookmark
MASH HCC ALCOHOL LIVER DISEASE PEDIATRIC LIVER DISEASE
Embassy of Education
Webcasts Abstract Library LiverQ Academy National Conference Regional Conferences
 
Back  
 
Reuters Health Information (2004-03-12): Biomarker combination may noninvasively diagnose cirrhosis

Drug & Device Development

Biomarker combination may noninvasively diagnose cirrhosis

Last Updated: 2004-03-12 13:10:23 -0400 (Reuters Health)

NEW YORK (Reuters Health) - In patients with liver disease, a new technique for analyzing profiles of serum protein N-glycans may obviate the need for liver biopsy to diagnose cirrhosis. The approach, referred to by its developers as "clinical glycomics" technology, is described in the March 7th online edition of Nature Medicine.

Dr. Nico Callewaert of Ghent University, Belgium and colleagues found that the combined use of this new set of biomarkers along with an older one makes it possible to diagnosis cirrhosis with 100% specificity and far higher sensitivity than had been possible with existing techniques. The marker combination, they note "did not yield any false positives among patients who were liver biopsy candidates, and the sensitivity of detection was 75% for compensated cirrhosis and 100% for decompensated cases."

The older set of biomarkers, called FibroTest, is a surrogate marker of liver fibrosis that is based on analysis of alpha2-macroglobulin, haptoglobin, apolipoprotein A1, total bilirubin and gamma glutamyl transpeptidase. The newer set, GlycoCirrhoTest, is derived from DNA sequencer-based profiling of serum protein N-glycans.

GlycoCirrhoTest distinguishes patients with compensated cirrhosis from patients with noncirrhotic chronic liver disease "by measuring just two easily detectable peaks" in the profile, according to the investigators. GlycoCirrhoTest results also correlate strongly with fibrosis stage.

As well as obviating the need for biopsy in many patients, the use of the combination of tests, the researchers conclude, "could be of considerable importance in monitoring the progression of chronic liver disease." Furthermore, "regular application would yield a warning signal for cirrhosis-related, life-threatening complications."

Nature Medicine 2004:

 
 
 
 

Subscribe

Be the first to know about our latest upcoming programs and events!

CLDF

Follow us

The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2025 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.